The Biochemical Assessments of Cellular Oxidant - Antioxidant Status and Lipid Profile for Some of COVID-19 Vaccines (Pfizer, AstraZeneca and Sinopharm) in Vaccinated People of Wasit Province in Iraq

Background: Coronaviruses (SARS-CoV-2) cause COVID-19 pandemic in March, 2020, after Chinese scientists published the genome of virus vaccine manufacturer produced several vaccines that aimed to induce a humoral and cellular immune response prevent fatality harm caused by COVID-19. Existing study evaluate biochemical efficiency some (Pfizer, AstraZeneca Sinopharm) vaccinated people Wasit Province Iraq lipid profile estimation, Human SOD1 (Superoxide Dismutase 1, Soluble) Malondialdehyde (MDA).Methods: The current sample included (55) individuals whom with two shots one three did not suffer from chronic health problems, control group (35) unvaccinated both genders. Their age ranges 18-45 years, they were divided into (18-31 32-45 years) their vaccination history was confirmed according special form. blood samples collected fasting 2-4 weeks post second dose for purpose conducting profile, SOD MDA.RESULTS: data serous endogenous oxidative–antioxidants balance showed variation concentrations malondialdehyde (MDA), its significant increase (P≤0.05) observed those Pfizer first range (31-18 insignificant decrease (P> 0.05) Sinopharm genders comparing group. Besides, findings estimating serum level enzyme Superoxide dismutase (SOD) significantly different between this all Additionally, levels (TG, LDL, HDL VLDL) changed (P>0.05) compared (unvaccinated individuals) except cleared cholesterol among group.Conclusion: present targeted have shown high efficacy safely on body oxidation heart terms assessment (MDA, profile) healthy participants.